Organic Chemistry · Chapter 7: Aldehydes & Ketones II

Question

To push the reaction in a retro-aldol direction, ____ is applied.

Answer

To push the reaction in a retro-aldol direction, aqueous base is added and heat is applied.
To push the reaction in a retro-aldol direction, aqueous base is added and heat is applied.
Note: If there are multiple aldehydes or ketones, we cannot easily control which will act as the nucleophile and which will act as the electrophile, and a mixture of products will result. This can be prevented if one of the molecules has no α-hydrogens because the α-carbons are quaternary (like benzaldehyde).
Note: Mixture of products can be prevented if one of the molecules has no α-hydrogens because the α-carbons are quaternary (like benzaldehyde).
Note: See the conjugated product below, α,ß-unsaturated carbonyl compound, it can be later used in Michael addition reaction: which eventually gives you a 1,4-carbonyl product.

Keep this card coming back until it sticks

Sign up free and spaced repetition will bring Chapter 7: Aldehydes & Ketones II cards back right before you forget them.

Continue studying — sign up free

More cards in Chapter 7: Aldehydes & Ketones II

____ - carbon is adjacent to the carbonyl carbon.

Through ____, oxygen pulls some of the electron density out of these α-Hydrogens bonded to Carbons, weakening them.

Through induction, oxygen pulls some of the ____ out of these α-Hydrogens bonded to Carbons, weakening them.

Through induction, oxygen pulls some of the electron density out of these α-Hydrogens bonded to Carbons, ____ them.

Oxygen pulling on C-H bonds with α-hydrogens, makes it relatively easy to ____ the α -carbon of an aldehyde or ketone.

The ____ of α -hydrogens is augmented by resonance stabilization of the conjugate base.

← All cards in Chapter 7: Aldehydes & Ketones II