Organic Chemistry · Chapter 7: Aldehydes & Ketones II

Question

Michael addition reaction is the one in which the ____.

Answer

Michael addition reaction is the one in which the carbanion of enolate attacks an α,β-unsaturated carbonyl compound.
Michael addition reaction is the one in which the carbanion of enolate attacks an α , β -unsaturated carbonyl compound.
Note ↓: The mechanism of the Michael addition includes nucleophilic attack by the enolate ion on the ß-carbon of the unsaturated carbonyl compound (the Michael “acceptor”), followed by protonation of the resulting enolate.
Note ↑: As the mechanism indicates, the reaction works because of the nucleophilic potential of the α-carbon of an enolate and the electrophilic reactivity of the ß-carbon of an α,ß-unsaturated carbonyl compound.
Note ↓: The synthetic sequence of a Michael addition followed by an intramolecular aldol condensation is also called a Robinson annulation. The Robinson annulation reaction produces new cyclic enones.
Fun Fact ↓:

Keep this card coming back until it sticks

Sign up free and spaced repetition will bring Chapter 7: Aldehydes & Ketones II cards back right before you forget them.

Continue studying — sign up free

More cards in Chapter 7: Aldehydes & Ketones II

____ - carbon is adjacent to the carbonyl carbon.

Through ____, oxygen pulls some of the electron density out of these α-Hydrogens bonded to Carbons, weakening them.

Through induction, oxygen pulls some of the ____ out of these α-Hydrogens bonded to Carbons, weakening them.

Through induction, oxygen pulls some of the electron density out of these α-Hydrogens bonded to Carbons, ____ them.

Oxygen pulling on C-H bonds with α-hydrogens, makes it relatively easy to ____ the α -carbon of an aldehyde or ketone.

The ____ of α -hydrogens is augmented by resonance stabilization of the conjugate base.

← All cards in Chapter 7: Aldehydes & Ketones II