Organic Chemistry · Chapter 7: Aldehydes & Ketones II

Question

Aldol condensations are most useful if ____.

Answer

Aldol condensations are most useful if we only use one type of aldehyde or ketone.
Aldol condensations are most useful if we only use one type of aldehyde or ketone.
Note: If there are multiple aldehydes or ketones, we cannot easily control which will act as the nucleophile and which will act as the electrophile, and a mixture of products will result. This can be prevented if one of the molecules has no α-hydrogens because the α-carbons are quaternary (like benzaldehyde).
Note: See the conjugated product below, α,ß-unsaturated carbonyl compound, it can be later used in Michael addition reaction: which eventually gives you a 1,4-carbonyl product.

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More cards in Chapter 7: Aldehydes & Ketones II

____ - carbon is adjacent to the carbonyl carbon.

Through ____, oxygen pulls some of the electron density out of these α-Hydrogens bonded to Carbons, weakening them.

Through induction, oxygen pulls some of the ____ out of these α-Hydrogens bonded to Carbons, weakening them.

Through induction, oxygen pulls some of the electron density out of these α-Hydrogens bonded to Carbons, ____ them.

Oxygen pulling on C-H bonds with α-hydrogens, makes it relatively easy to ____ the α -carbon of an aldehyde or ketone.

The ____ of α -hydrogens is augmented by resonance stabilization of the conjugate base.

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