Question
To determine the absolute configuration at a chiral center:
1. ____.Answer
To determine the absolute configuration at a chiral center:
1. Assign priority by atomic number.2. Arrange the molecule with the lowest-priority substituent in the back (or invert the stereochemistry by switching two substituents).
3. Draw a circle around the molecule from highest to lowest priority (1 to 2 to 3)
4. Name the molecule accordingly: Clockwise = (R); counterclockwise = (S).
Note: Chirality can also be thought of as handedness. In fact, one of the easiest visualizations of chirality is to think of your own hands, as shown in Figure 2.9. Although essentially identical, your left hand will not be able to fit into a right-handed glove.
Note: A simple 180° rotation around a vertical axis, as shown in Figure 2.11, allows the compound to be superimposed upon its mirror image.
Note: For example, the C-1 carbon atom in 1-bromo-1-chloroethane has four different substituents. As shown in Figure 2.10, this molecule is chiral because it is not superimposable on its mirror image.
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____ are characteristics of processes that don’t change the composition of matter, such as melting point, boiling point, solubility, odor,…
Physical properties are characteristics of processes that don’t change the composition of matter, such as ____.
____ have to do with the reactivity of the molecule with other molecules and result in changes in chemical composition.
Chemical properties have to do with ____.
In organic chemistry, the chemical properties of a compound are generally dictated by the ____ in the molecule.
The only thing that ____ isomers share is their molecular formula.