Biochemistry

Chapter 1: Amino Acids, Peptides, & Proteins

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Amide bonds are rigid because of ____.

Breaking a peptide bond is a ____ reaction.

____ in amino acids is the linear sequence of amino acids in a peptide.

Primary structure in amino acids is ____.

Primary structure is stabilized by ____.

____ structure is stabilized by peptide bonds.

____ structure is the local structure of neighboring amino acids.

Secondary structure is ____.

____ structure is stabilized by hydrogen bonding between amino groups and nonadjacent carboxyl groups.

Secondary structure is stabilized by ____.

α - helices are c____oils around a central axis.

____ are clockwise coils around a central axis.

____ are rippled strands that can be parallel or antiparallel.

β - pleated sheets are ____.

____ can interrupt secondary structure because of its rigid cyclic structure.

Proline can interrupt s____tructure because of its rigid cyclic structure.

Proline can interrupt secondary structure because of ____.

____ structure is the three-dimensional shape of a single polypeptide chain.

Tertiary structure is ____.

____ structure is stabilized by hydrophobic interactions, acid–base interactions (salt bridges), hydrogen bonding, and disulfide bonds.

Tertiary structure is stabilized by ____.

____ push hydrophobic R groups to the interior of a protein.

Hydrophobic interactions ____

Hydrophobic interactions between amino acids ____ Gibbs free energy.

Hydrophobic interactions between amino acids increases ____.

Disulfide bonds occur when two cysteine molecules are oxidized and create a covalent bond to form ____.

Disulfide bonds occur when two ____ molecules are oxidized and create a covalent bond to form cystine.

____ occur when two cysteine molecules are oxidized and create a covalent bond to form cystine.

Disulfide bonds occur when two cysteine molecules are ____ and create a covalent bond to form cystine.

____ structure is the interaction between peptides in proteins that contain multiple subunits.

Quaternary structure is ____.

Proteins with covalently attached molecules are termed ____.

Proteins with ____ are termed conjugated proteins.

The attached molecule to conjugated proteins is a ____, and may be a metal ion, vitamin, lipid, carbohydrate, or nucleic acid.

The attached molecule to conjugated proteins is a prosthetic group, and may be a ____.

The attached molecule to ____ proteins is a prosthetic group, and may be a metal ion, vitamin, lipid, carbohydrate, or nucleic acid.

Both ____ can lead to loss of three-dimensional protein structure.

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