Organic Chemistry · Chapter 8: Carboxylic Acids

Question

Most to Least Reactive Carboxylic Derivative
____.

Answer

Most to Least Reactive Carboxylic Derivative
Acid Halide → Anhydride → Carboxylic Acid → Ester → Amide.
Most to Least Reactive Carboxylic Derivative Acid Halide → Anhydride → Carboxylic Acid → Ester → Amide.
Note: Took quite some effort to edit and put together this chart. Stare at it. Engrain it in your brain.
In Summary: As the basicity of Z increases, the stability of RCOZ increases because of added resonance stabilization.

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