General Chemistry · 1EK: General Chemistry

Question

Whenever a carbonyl appears on the MCAT®, think about two things:
1. ____

Answer

Whenever a carbonyl appears on the MCAT®, think about two things:
1. Planar stereochemistry 2. Polarity: partial negative charge on oxygen, partial positive charge on carbon
Whenever a carbonyl appears on the MCAT®, think about two things: 1. Planar stereochemistry 2. Polarity: partial negati…
Note: Both of these properties make carbonyls excellent electrophiles. The planar stereochemistry of a carbonyl leaves open space above and below, reducing steric hindrance and making it more receptive to attack. The partial positive charge on the carbonyl carbon makes it prone to nucleophilic attack. The partial negative charge on the oxygen is easily protonated.

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