Question
Peptide bond formation is
a typical nucleophilic substitution, or technically a (addition + elimination) reaction, with a____s the leaving group.
Answer
Peptide bond formation is
a typical nucleophilic substitution, or technically a (addition + elimination) reaction, with an alcohol as the leaving group.
Note: Since the initial attack is by a nucleophile, and the overall result is substitution, it would seem reasonable to describe the reaction as nucleophilic substitution. However, the reaction happens in two distinct stages. The first involves an addition reaction, which is followed by an elimination reaction. So the mechanism is also known as nucleophilic addition/elimination.
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