Question
Cyclic amides can be formed in intramolecular reactions and are called ____.
Answer
Cyclic amides can be formed in intramolecular reactions and are called lactams.
Note: Although amides are the most stable of the carboxylic acid derivatives, they are unstable in small rings sizes because of ring strain. In the case of ß-lactams, which are found in several types of antibiotics, nucleophiles can easily react with their four member ring.
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