Question
GLUT 2 follows first-order kinetics because ____.
Answer
GLUT 2 follows first-order kinetics because the Km of GLUT 2 is quite high (~15 mM), which means that the liver will pick up glucose in proportion to its concentration in the blood.
Real World: Diabetes mellitus is caused by a disruption of the insulin/GLUT 4 mechanism. In type 1 diabetes, insulin is absent and cannot stimulate the insulin receptor. In type 2 diabetes, the receptor becomes insensitive to insulin and fails to bring GLUT 4 transporters to the cell surface. In both cases, blood glucose rises, leading to immediate symptoms (increased urination, increased thirst, ketoacidosis) and long-term symptoms (blindness, heart attacks, strokes, nerve damage).
Keep this card coming back until it sticks
Sign up free and spaced repetition will bring Chapter 9: Carbohydrate Metabolism I cards back right before you forget them.
Continue studying — sign up freeMore cards in Chapter 9: Carbohydrate Metabolism I
Glucose entry into most cells is driven by ____.
Normal glucose concentration in peripheral blood is ____ mM.
There are four glucose transporters, called ____.
Sodium-Dependent Glucose Transporters are called ____.
GLUT 2 is a ____-affinity transporter in hepatocytes and pancreatic cells.
GLUT 2 is a low-affinity transporter in ____ cells.